Homocysteine, a Proinflammatory and Proatherosclerotic Factor
نویسندگان
چکیده
منابع مشابه
Homocysteine, a proinflammatory and proatherosclerotic factor: role of intracellular reactive oxygen species.
In 1969, McCully first described the association of hyperhomocysteinemia and vascular disease in a patient with elevated levels of homocysteine in plasma and urine due to a rare genetic deficiency of homocysteine metabolism.1 A large number of clinical studies have indicated that mild hyperhomocysteinemia, which occurs in approximately 5% to 7% of the general population, is also associated with...
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Background: Epidemiological research has shown that increased total homocysteine (tHcy) levels are associated with an increased risk of thromboembolic disease; however, controversy still exists over which subtype of stroke is allied to hyperhomocysteinemia. This study aimed to investigate whether elevated tHcy is an independent risk factor for ischemic stroke and to compare tHcy levels in patie...
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Disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (BHMT) coding gene, leads to decrease in S-adenosyl methionine (SAM) synthesis which takes part in DNA methylation as a methyl donor. As a result, it can promote hypo-methylation of DNA, chromosome instability, and chromosome missegregation, which in turn is one of t...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000089561.87997.cf